28936-94-9, 8-Benzyl-1,3,8-triazaspiro[4.5]decane-2,4-dione is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
In a 20 L reactor 2.4 kg sodium hydroxide were dissolved in 10 L water. The solution was mixed with 614 g 1.38 (8-benzyl-1 ,3,8-triaza-spiro[4.5]decane-2,4-dione) and the resulting reaction suspension was heated to 80C. When 80C was reached, the reaction mixture was heated in steps of 10C. When the temperature reached 105C the mixture started to foam strongly. Stirring was continued at 108C overnight. The reaction mixture was cooled to 10C and 5 L concentrated hydrochloric acid were added dropwise to obtain a pH 7-8. During the addition the temperature was kept at 23C. The precipitate was filtered and dried in vacuo at 40C over 3 days, then at 80C overnight.Yield: 469.7 g I.39 (85% of theory), 28936-94-9
The synthetic route of 28936-94-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; DAHMANN, Georg; FIEGEN, Dennis; FLECK, Martin; HOFFMANN, Matthias; KLICIC, Jasna; EAST, Stephen, Peter; NAPIER, Spencer, Charles, R.; SCOTT, John; WO2012/101013; (2012); A1;,
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