276872-89-0, N-Boc-3-Methylenepiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of N-Boc-3-methylenepyrazdine (0.4 g) and 9-BBN (12 ml) was cooled to 0 C. for 30 min, and then warmed to room temperature for 2 h. Dioxane (20 ml), PdCl2 (0.05 g), K3PO4 (0.32 g) and 4-chloro-2-(4-chlorophenyl)-thieno[2,3-d]pyridzaine-7-carboxylic acid ethyl ester were heated at 90 C. over night. The reaction mixture was cooled, diluted with ethyl acetate and washed with water. The organic layer was washed with brine, dried over anhydrous Na2SO4 and evaporated. The residue was purified by flash chromatography (silica gel, PE_EA=5:10) to obtain 4-(1-Boc-3-piperidinemethy)-2-(4-chlorophenyl)-thieno[2,3-d]pyridazine-7-carboxylic acid ethyl ester as a solid (0.3 g). 1H-NMR (400 MHz, DMSO), delta 8.90 (s, 1H), 8.03 (m, 2H), 7.63 (m, 2H), 4.54 (m, 2H), 3.73 (s, 2H), 3.32 (m, 2H), 3.28 (m, 1H), 2.82 (m, 2H), 2.09 (s, 1H), 1.78 (s, 1H), 1.64 (s, 1H), 1.44 (m, 3H), 1.39 (s, 1H), 1.32 (s, 9H). MS (EI): 515 (M+), 486, 458, 442, 414, 334, 332, 306, 304, 149, 57.
276872-89-0, 276872-89-0 N-Boc-3-Methylenepiperidine 11252594, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; Wu, Zhanggui; US2009/275585; (2009); A1;,
Piperidine – Wikipedia
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