With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.255051-14-0,4-(2-(Trifluoromethyl)phenyl)piperidine hydrochloride,as a common compound, the synthetic route is as follows.
255051-14-0, Example 4: Preparation of ( 6-Fluoro- [1,2,4] triazolo [4, 3-a]pyridin-3- (trifluoromethyl)phenyl)piperidin-1-yl>methanone Step B: To a solution of ethyl 6-fluoro- [1, 2, 4] triazolo [4, 3- a]pyridine-3-carboxylate (0.100 g, 0.478 mmol) in THF (5 mL) was added a solution of LiOH hydrate (0.040 g, 0.956 mmol) in 0 (2 mL) . The mixture stirred for 20 minutes and was then acidified to pH 6 with 2 N HC1 followed by subsequent concentration under reduced pressure. The resulting residue was added to a mixture of 4-(2- (trifluoromethyl) henyl) iperidine hydrochloride (5, 0.127 g, 0.478 mmol) , benzotriazole-l-yl-oxy-tris- (dimethylamino) -phosphonium hexafluorophosphate (0.423 g, 0.956 mmol), i-Pr2NEt (0.185 g, 1.43 ntmol) in DMF (4 mL) . The mixture stirred at ambient temperature for 16 hours and was then poured into 0 and extracted with EtOAc (30 mL) . The organic layer was washed with brine (2 x 30 raL) , dried over Na;SO , filtered, and concentrated under reduced pressure. The resulting residue was chromatographed over silica gel (0-50% E CAc in hexar.ee) and freeze dried to give ( 6-fluoro- [ 1 , 2,4] triazolo [4, 3- a]pyridin-3-yl ) ( 4- ( 2- (trifluoromethyl) henyl) piperidin-l- yDmethanone as a white solid (0.101 g, 53%); mp 168-170 C; NMR (300 MHz, CDCli) 8 9.18 (s, 1H) , 7.88 (m, 1H) , 7.66 (d, J = 7.5 Hz, 1H , 7.55-7.30 (m, 4H) , 5.76 (m, 1H) , 4.99 (m, 1H) , 3.40-3.30 (m, 2H) , 2.98 (m, 1H) , 2.03-1.76 (m, 4H) ; MS (ESI+ ) ra/z 393 [M>H] * .
As the paragraph descriping shows that 255051-14-0 is playing an increasingly important role.
Reference£º
Patent; THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; PETRUKHIN, Konstantin; CIOFFI, Christopher; JOHNSON, Graham; DOBRI, Nicoleta; FREEMAN, Emily; CHEN, Ping; CONLON, Michael; ZHU, Lei; WO2014/152013; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem