24686-78-0, 1-Benzoylpiperidin-4-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 57 {4-[({9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(methoxymethyl)tetrahydro-2-furanyl]-6-[(2,2-diphenylethyl)amino]-9H-purin-2-yl}methyl)amino]-1-piperidinyl}(phenyl)methanone The title compound was prepared by a similar method to example 6 using (2R,3R,4S,5R)-2-{2-(aminomethyl)-6-[(2,2-diphenylethyl)amino)-9H-purin-9-yl}-5-(methoxymethyl)tetrahydro-3,4-furandiol (310 mg, 0.63 mmol) (example 1), 1-benzoyl-4-piperidinone (128 mg, 0.63 mmol), sodium triacetoxyborohydride (200 mg, 0.90 mmol) and acetic acid (45 mg, 0.74 mmol). The product was purified by column chromatography on silica gel eluding with a solvent system of dichloromethane:methanol:ammonia (92:8:0.4) to give the title compound (300 mg) as an oil. MS: 679 (MH+). 1H NMR (CDCl3) delta=7.90 (1H, s), 7.45-7.20 (15H, m), 5.95-5.90 (2H, m), 4.50 (1H, br s), 4.45-4.20 (6H, m), 3.90 (2H, s), 3.70 (1H, br s), 3.65-3.55 (2H, m), 3.35 (3H, s), 3.05-2.80 (3H, m), 2.10-1.80 (2H, m), 1.50-1.30 (2H, m). Analysis: Found C, 64.35, H, 6.16, N, 13.63; C38H43N7O5.0.5H2O.0.33CH2Cl2 requires C, 64.38, H, 6.29, N, 13.71percent.
24686-78-0, The synthetic route of 24686-78-0 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Pfizer Inc; US6326359; (2001); B1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem