With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.236406-39-6,8-Boc-2,8-Diazaspiro[4.5]decane,as a common compound, the synthetic route is as follows.
General procedure: To a stirring solution of tert-butyl piperazine-1-carboxylate 5(3 mmol) or tert-butyl 2,8-diazaspiro[4.5]decane-8-carboxylate 8or in CH3CN (50 mL) was added 1-bromopropan-2-one or but-3-en-2-one (4 mmol) and K2CO3 (5 mmol) at room temperature.The mixturewas stirred for 3e4 h at room temperature and filtered.The filtrate was diluted by H2O (250 mL) and extracted by DCM(100 mL 3). The combined organic layer was washed by brine,dried over anhydrous MgSO4, filtered, and concentrated. The residuewas purified over silica gel column (DCM: MeOH 40: 1) toyield oils compounds 6a-b or 9a-b (yield, 52%e61%)., 236406-39-6
236406-39-6 8-Boc-2,8-Diazaspiro[4.5]decane 23282900, apiperidines compound, is more and more widely used in various fields.
Reference£º
Article; Wang, Apeng; Lv, Kai; Tao, Zeyu; Gu, Jian; Fu, Lei; Liu, Mingliang; Wan, Baojie; Franzblau, Scott G.; Ma, Chao; Ma, Xican; Han, Bing; Wang, Aoyu; Xu, Shijie; Lu, Yu; European Journal of Medicinal Chemistry; vol. 181; (2019);,
Piperidine – Wikipedia
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