With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22990-34-7,2-(4-Piperidyl)-2-propanol,as a common compound, the synthetic route is as follows.,22990-34-7
(a) A/-(2,2,2-Trifluoroethyl)-2-[4-(1-hydroxy-1-methyl-ethyl)-piperidinyl]-4-methy nitro-benzoic acid amideA mixture of 4-(1-hydroxy-1-methyl-ethyl)-piperidine (24 mg, 0.17 mmol), NaH-suspension (50% in mineral oil, 8 mg, -0.17 mmol) and THF (1 ml_) is stirred for 10 min. Then, Lambda/-(2,2,2- trifluoro-ethyl)-2-fluoro-4-methylamino-5-nitro-benzoic acid amide is added and it is stirred for 1.5 h. The mixture is diluted with EtOAc, washed with water, concentrated, dried and directly used in the next step.HPLC Rt = 1.34 min (method A). MS m/z: 419 [M+H]+.
22990-34-7 2-(4-Piperidyl)-2-propanol 5200321, apiperidines compound, is more and more widely used in various.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; PRIEPKE, Henning; DOODS, Henri; HEIM-RIETHER, Alexander; KUELZER, Raimund; PFAU, Roland; RUDOLF, Klaus; STENKAMP, Dirk; WO2012/76673; (2012); A1;,
Piperidine – Wikipedia
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