With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.216854-23-8,(S)-tert-Butyl piperidin-3-ylcarbamate,as a common compound, the synthetic route is as follows.
A solution of tot-butyl (3S)-piperidin-3-ylcarbamate (499 mg, 0.00249 mol; CNH Technologies) and triethylamine (0.52 mL, 0.0037 mol) dissolved in methylene chloride (5.0 mL, 0.078 mol) was cooled to 0 C and to this was added 3-chloro-2-methylbenzenesulfonyl chloride (0.62 g, 0.0027 mol) (6:56). After stirring for 10 min. the reaction mixture was allowed to gradually warm to rt while stirring for 24h. The reaction was quenched with water (1:09), diluted with EtOAc and 0. IN HC1 and brine were added. The layers were separated and the organic layer was washed with saturated sodium bicarbonate, brine, dried (Na2S04), filtered, and concentrated in-vacuo to afford 1.03g of the desired product as awhite solid. The .HNMR confirmed that the desired product was isolated.
The synthetic route of 216854-23-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; INCYTE CORPORATION; WO2006/20598; (2006); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem