With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21319-53-9,1-Benzylpiperidine-2-carboxylic acid,as a common compound, the synthetic route is as follows.
General procedure: The fragment carboxylic acid (0.35 mmol) was dissolved in dimethylformamide (0.2 M, 1.75 mL), then 14 (42.6 mg, 0.35 mmol), HBTU (128 mg, 0.34 mmol), and HOBT (51.8 mg, 0.38 mmol) were added, followed by diisopropylethylamine (175 muL, 1.047 mmol). The reaction was stirred at 23 C for 16 h. TLC at 16 h showed conversion to product. The reaction was quenched with H2O (5 mL) and extracted with DCM (3 x 5 mL). The combined organic layers were washed with 1 M HCl (10 mL), saturated aqueous NaHCO3 (10 mL), and saturated aqueous NaCl (10 mL). The organic layer was dried over MgSO4, filtered, and evaporated. Purification with flash column chromatography with CH3OH/CH2Cl2 ( CH3OH gradient 0 ? 5 %).
21319-53-9, The synthetic route of 21319-53-9 has been constantly updated, and we look forward to future research findings.
Reference：
Article; McShan, Danielle; Kathman, Stefan; Lowe, Brittiney; Xu, Ziyang; Zhan, Jennifer; Statsyuk, Alexander; Ogungbe, Ifedayo Victor; Bioorganic and Medicinal Chemistry Letters; vol. 25; 20; (2015); p. 4509 – 4512;,
Piperidine – Wikipedia
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