With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21168-72-9,2-(4-(Aminomethyl)piperidin-1-yl)ethanol,as a common compound, the synthetic route is as follows.
[00351 ] To the solution of compound 2-(4-(aminomethyl)piperidin-1 – yl)ethanol (150 mg, 0.95 mmol) and compound 6-chloro-3-(3- (trifluoromethoxy)phenyl)imidazo[1 ,2-b]pyridazine (200 mg, 0.64 mmol) in 3 ml_ DMSO was added DIEA (0.3 ml_, 1 .37 mmol) and 10 mg CsF, the solvent was stirred for 5 h at 120 C, Then the mixture was purified by HPLC to afford the compound 2-(4-(((3-(3-(trifluoromethoxy)phenyl)imidazo[1 ,2-b]pyridazin-6- yl)amino)methyl)cyclohexyl)ethanol (34 mg, 8.2 %) as a brown solid. [00352] 1 H-NMR (CDCI3/400 MHz): delta 8.61 (s, 1 H), 8.20 – 8.25 (m, 1 H), 7.95 – 8.05 (m, 2 H), 7.66 (t, J = 4.4 Hz, 1 H), 7.21 – 7.28 (m, 1 H), 3.80 – 3.90 (m, 2 H), 3.62 – 3.75 (m, 2 H), 3.37 (d, J = 6.4 Hz, 2 H), 3.21 (t, J = 5.2 Hz, 2 H), 2.91 – 3.09 (m, 2 H), 2.10 (d, J = 14.0 Hz, 2 H), 1 .51 – 1 .69 (m, 2 H). MS (ES+, m/z): (M+H)+: 435.5.
21168-72-9, The synthetic route of 21168-72-9 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; TOLERO PHARMACEUTICALS, INC.; XU, Yong; BRENNING, Benjamin, Gary; KULTGEN, Steven, G.; LIU, Xiaohui; SAUNDERS, Michael; HO, Koc-Kan; WO2013/13188; (2013); A1;,
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