191732-76-0, 5-Amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
In a 4 mL glass vial, a mixture of 5-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3- dione(30 mg, 0.110 mmol, 1 equiv) and acetyl chloride (26 pL, 0.220 mmol, 2 equiv) in THF (1.8mL, 0.1 M) was heated to reflux overnight. The reaction mixture was filtered, and the filter cake was washed with Et20 to give the title compound as a white solid (27 mg, 47%), that was used without further purification. ?HNMR(500 MHz, DMSO-d6) 11.11 (s, 1H), 10.63 (s, 1H), 8.24 (d, J 1.5 Hz, 1H), 7.91 -7.83 (m, 2H), 5.11 (dd, J 12.8, 5.4 Hz, 1H), 2.88 (ddd, J= 17.0, 13.8, 5.4 Hz, 1H), 2.63 -2.46 (m, 2H), 2.13 (s, 3H), 2.09-2.00 (m, 1H); MS (ESI) calcd for C15H14N305[M+H] 316.09, found 316.23.
191732-76-0, 191732-76-0 5-Amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione 9816958, apiperidines compound, is more and more widely used in various fields.
Reference：
Patent; DANA-FARBER CANCER INSTITUTE, INC.; BRADNER, James; ROBERTS, Justin; BEHMAN, Nabet; WINTER, Georg; PHILLIPS, Andrews, J.; HEFFERNAN, Timothy, P.; BUCKLEY, Dennis; (617 pag.)WO2018/148440; (2018); A1;,
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