With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161975-39-9,tert-Butyl 4-(((methylsulfonyl)oxy)methyl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.
Amixture of 2 (1eq, 11.72 g, 40 mmol) and lithium bromide (5eq,17.20 g, 200 mmol) in acetone (80 mL) was heated to reflux overnight.The mixture was evaporated, then the residue was partitionedbetween EtOAc and water. The organic layer was washedwith s brine, dried over Na2SO4, filtered, and evaporated to offer the title product 3 as pale yellow oil (9.46 g, 85.40% yield)., 161975-39-9
161975-39-9 tert-Butyl 4-(((methylsulfonyl)oxy)methyl)piperidine-1-carboxylate 2765838, apiperidines compound, is more and more widely used in various fields.
Reference：
Article; He, Linhong; Pei, Heying; Zhang, Chufeng; Shao, Mingfeng; Li, Dan; Tang, Mingli; Wang, Taijing; Chen, Xiaoxin; Xiang, Mingli; Chen, Lijuan; European Journal of Medicinal Chemistry; vol. 145; (2018); p. 96 – 112;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem