With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161609-84-3,Benzyl 4-cyanopiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.
(3) The above-mentioned compound (1.42 g) was dissolved in N-methyl-2-pyrrolidone (60 mL), and sodium azide (1.13 g) and triethylamine hydrochloride (1.24 g) were added thereto. The mixture was stirred at 150C for 6 hr. 1 mol/L Hydrochloric acid was added to the reaction mixture to adjust its pH to 1, and the mixture was extracted with ethyl acetate. 10% Aqueous sodium hydroxide solution was added to the extract, and the mixture was washed with diethyl ether. The aqueous layer was adjusted to pH 1 with concentrated hydrochloric acid, and the mixture was extracted with ethyl acetate. The extract was dried and concentrated under reduced pressure. Trifluoroacetic acid (6 mL), tert-butanol (0.900 g) and concentrated sulfuric acid (0.16 mL) were added to the residue, and the mixture was stirred at room temperature for 3 days. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was washed successively with 2.5 mol/L aqueous sodium hydroxide solution and brine, dried, and concentrated under reduced pressure. The residue was purified by HPLC to give 1-benzyloxycarbonyl-4-(2-tert-butyl-2H-tetrazol-5-yl)piperidine (140 mg) as a white solid.
161609-84-3, 161609-84-3 Benzyl 4-cyanopiperidine-1-carboxylate 22028286, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; WELFIDE CORPORATION; EP1308439; (2003); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem