With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161491-24-3,1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate,as a common compound, the synthetic route is as follows.
In a reaction flask, methyl N-Boc-3-methylcarboxylate-4-pyridinone 25g (0.1mol) was added to methanol 300mL, then add ammonium acetate 22g (0.3mol), the reaction overnight, TLC monitoring The reaction of raw materials was complete, spin the methanol, add water 900mL, the reaction mixture was extracted three times with 300mL of dichloromethane, the combined organic phase was dried over anhydrous sodium sulfate, and dried to give a red oily liquid N-Boc-3-carboxylic acid methyl ester Amino-3-ene-piperidine 22g, 161491-24-3
161491-24-3 1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate 11276893, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; Wang Huiqin; (16 pag.)CN107151247; (2017); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem