With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.157327-41-8,1-Boc-3-[(Dimethylamino)methylene]-4-oxopiperidine,as a common compound, the synthetic route is as follows.
Example 21ferf-Butyl 2-((3-cyanophenyl)amino)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)- carboxylate[00164]fe/f-Butyl 3-((dimethylamino)methylene)-4-oxopiperidine-1 -carboxylate (1 .1 g, 4.33 mmol) is dissolved in abs. EtOH (20 mL), and 1 -(3-cyanophenyl)guanidine (0.46 g, 2.90 mmol) is added. The mixture is heated at 100 C for 16 h, then cooled and evaporated to dryness. Purification of the residue by flash column chromatography provides the title compound (0.62 g, 60%) as a yellow solid.1H NMR (CDCI3), deltaEta, 1 .49 (s, 9H), 2.85 (t, 2H), 3.73 (t, 2H), 4.51 (s, 2H), 7.24 – 7.41 (m, 3H), 7.62 – 7.66 (m, 1 H), 8.20 (s, 1 H), 8.24 (s, 1 H)LC/MS (M+H)+ = 352
157327-41-8, 157327-41-8 1-Boc-3-[(Dimethylamino)methylene]-4-oxopiperidine 53395404, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; MERZ PHARMA GMBH & CO. KGAA; ABEL, Ulrich; KRUEGER, Bjoern; KUBAS, Holger; MEYER, Udo; ZEMRIBO, Ronalds; SMITS, Gints; WO2012/85167; (2012); A1;,
Piperidine – Wikipedia
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