With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.148763-41-1,Methyl N-Boc-piperidine-3-carboxylate,as a common compound, the synthetic route is as follows.
Step-1: Preparation of intermediate-43a; To a stirred solution of intermediate 42 (750 mg, 3.08 mmol) in THF (10 mL) was added a solution of lithium aluminum hydride in THF (1 M in THF, 2.16 mL) at 0 C. The reaction mass was stirred at 0 C. for 2 h. The reaction mass was quenched with sodium sulfate decahydrate. The reaction mass was filtered through a bed of celite and washed with ethyl acetate. The filtrate was evaporated to dryness. The residue was purified by flash column chromatography to afford intermediate 43a (660 mg, >99%)., 148763-41-1
The synthetic route of 148763-41-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; H. LUNDBECK A/S; US2011/92475; (2011); A1;,
Piperidine – Wikipedia
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