With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1454-53-1,Ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride,as a common compound, the synthetic route is as follows.
A suspension of ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (5a) (19.5 g, 68.7 mmol) and guanidine carbonate (19.5 g, 41.23 mmol) in ethanol (170 mL) was heated for 16 hours at 120C. The solvent was removed under reduced pressure, reconstituted in acetonitrile where the crude precipitated and was isolated by filtration. The solid was used as such in the next step without further purification. 1H NMR (300 MHz, DMSO-d6) d ppm 2.35 – 2.46 (m, 2 H), 2.57 – 2.65 (m, 2 H), 3.04 (s, 2 H), 3.60 (s, 2 H), 6.28 (br. s., 2 H), 7.27 (dt, J=8.7, 4.5 Hz, 1 H), 7.31 – 7.36 (m, 4 H), 10.74 (br. s., 1 H). MS m/z: 257 [M+H]+.
1454-53-1, The synthetic route of 1454-53-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; McGowan, David C.; Herschke, Florence; Khamlichi, Mourad D.; Rosauro, Mari Luz; Benedicto, Sara M. Perez; Pauwels, Frederik; Stoops, Bart; Pande, Vineet; Scholliers, Annick; Van Schoubroeck, Bertrand; Mostmans, Wendy; Van Dijck, Kris; Thone, Tine; Horton, Helen; Fanning, Gregory; Jonckers, Tim H.M.; Raboisson, Pierre; Bioorganic and Medicinal Chemistry Letters; vol. 28; 19; (2018); p. 3216 – 3221;,
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