Li, Lun; Liu, Yu-Cheng; Shi, Hang published the article 《Nickel-Catalyzed Enantioselective α-Alkenylation of N-Sulfonyl Amines: Modular Access to Chiral α-Branched Amines》. Keywords: allylic amine preparation enantioselective diastereoselective; sulfonyl amine alkyne alkenylation nickel catalyst.They researched the compound: 1-Boc-4-(Aminomethyl)piperidine( cas:144222-22-0 ).Computed Properties of C11H22N2O2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:144222-22-0) here.
Herein, an atom-economical, modular method for nickel-catalyzed enantioselective α-alkenylation of readily available linear N-sulfonyl amines RS(O)2NHCH2R1 (R = Me, 2,4,6-trimethylphenyl, 4-methoxyphenyl, etc.; R1 = Et, Ph, thiophen-2-yl, etc.) with alkynes R2CCR3 (R2 = trimethylsilyl, Ph, 4-methylphenyl, etc.; R3 = 3-methylbutyl, Ph, naphthalen-2-yl, etc.) to afford a wide variety of allylic amines RS(O)2NHCH(R1)C(R2)=CH(R3) without the need for exogenous oxidants, reductants, or activating reagents was described. The method provides a platform for constructing chiral α-branched amines, as well as derivatives such as α-amino amides I and β-amino alcs. 2,4,6-(CH3)3C6H2S(O)2NHCH(R1)CH(R2)OH, which can be conveniently accessed from the newly introduced alkene. Based on the generality, versatility, and high atom economy of this method, the method will have broad synthetic utility.
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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem