With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.138007-24-6,tert-Butyl piperidine-4-carboxylate,as a common compound, the synthetic route is as follows.
Example 87Ethyl 5-chloro-6-(4-{[(4-methylbenzyl)sulfonyl]carbamoyl}piperidin-l-yl)-2-[(2- oxopyrrolidin-l-yl)methyl]nicotinate5 (a) Ethyl 6-[4-(/e^-butoxycarbonyl)piperidin-l-yl]-5-chloro-2-[(2-oxopyrrolidin-l- yl)methyl]nicotinateEthyl 5,6-dichloro-2-[(2-oxopyrrolidin-l-yl)methyl]nicotinate (Example 85(d)) (3.2 g, 9.96 mmol) and tert-bntyl piperidine-4-carboxylate (2.77 g, 15 mmol) were dissolved in DIPEA o (4.4 mL, 24.9 mmol) and iV-methyl-2-pyrrolidone (30 mL), the reaction mixture was heated at 1400C for 1.5 h. Water and DCM were added, the organic phase was washed with 0.5 M HCl, sat. NaHCO3 and water, dried (MgSO4) and concentrated in vacuo. The residue was purified by flash chromatography, DCMiMeOH 100:0 to 90:10 as eluent, to give ethyl 6-[4-(te7Y-butoxycarbonyl)piperidin-l-yl]-5-chloro-2-[(2-oxopyrrolidin-l- 5 yl)methyl]nicotinate. Yield: 3.1 g (67percent).1H-NMR (500 MHz5 CDCl3) delta 1.37 (3H, t), 1.45 (9H, s), 1.80 (2H, m), 1.95 (2H, m), 2.08 (2H, m), 2.40-2.50 (3H, m), 3.00 (2H5 m), 3.49 (2H5 m), 4.04 (2H, m), 4.32 (2H5 q), 4.87 (2H, s), 8.11 (lH, s)., 138007-24-6
As the paragraph descriping shows that 138007-24-6 is playing an increasingly important role.
Reference£º
Patent; ASTRAZENECA AB; WO2008/85119; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem