With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.134441-93-3,(S)-1-Boc-2-(Hydroxymethyl)piperidine,as a common compound, the synthetic route is as follows.
General procedure: To a solution of (COCl)2 (1.2mmol) in DCM (10mL) cooled to -78C was added DMSO (1.5mmol). The carbamate protected pipecolinol 10 (a, b, c) (1mmol) was then added drop wise over a period of 5min. The reaction mixture was brought to -50C in 15min and Et3N (3mmol) was added over a period of 5min. It was then stirred for 10min at the same temperature and further stirred at rt for 15min. The reaction mixture was further diluted with DCM (10mL) and the organic layer was washed with very dil HCl (0.1N, 10mL¡Á2) and brine solution (10mL¡Á2). It was then dried over anhyd Na2SO4 and concentrated under reduced pressure to afford aldehyde 11 (a, b, c) as a thick liquid, which without any further purification was immediately consumed for the next reaction.
134441-93-3, As the paragraph descriping shows that 134441-93-3 is playing an increasingly important role.
Reference£º
Article; Bhat, Chinmay; Tilve, Santosh G.; Tetrahedron; vol. 69; 51; (2013); p. 10876 – 10883;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem