Brief introduction of 13360-65-1

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 13360-65-1 help many people in the next few years. COA of Formula: C8H12N2.

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 13360-65-1, Name is 3-Ethyl-2,5-dimethylpyrazine. In a document, author is Leghari, Qurratul-ain, introducing its new discovery. COA of Formula: C8H12N2.

Evaluation of anti-inflammatory and antibacterial potential of newly synthesized 4-(2-Keto-1-benzimidazollinyl) derivatives of piperidine

Benzimidazole and its derivatives found variety of biological activities, for the searching of its potent anti-inflammatory analogues, we synthesized four novel 4-(2-keto-1-benzimidazollinyl) piperidine derivatives (Q1 to Q4) by refluxing piperidine with substituted imidazole and subjected to in-vitro anti-inflammatory (ROS, NO) and antibacterial activities, structures were elucidated using spectroscopic techniques. Results revealed that compound Q1 showed most effective anti-inflammatory activity with IC50 7.6 +/- 1.3 mu g/ml compared with standard Ibuprofen having IC50 11.2 +/- 1.9 mu g/mL. Compound Q3 showed good activity for Nitrite accumulation by stimulating macrophages test similar to standard N-G Methyl L-arginine acetate with IC50 value 24.2 +/- 0.8 mu g/mL. The antibacterial activity of these compounds were evaluated against selected Gram+ve E. faecalis, C. diphtheriae, S. aureus and Gram -ve organism E. coli, Enterobacter aerogenes and P. aeruginosa. Synthesized compounds showed low to moderate level of antibacterial activity Q1 showed the highest antibacterial activity against Enterococcus faecalis and Escherichia coli with zone of inhibition 18mm and Q3 showed highest activity against Corynebacterium diptheriae (ZOI:18mm). Structure-activity relationship (SAR) study revealed that among all the synthesized compounds unsubstituted naphthalene (Q1) and phenyl (Q3) ring containing derivatives were most potent.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 13360-65-1 help many people in the next few years. COA of Formula: C8H12N2.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem