With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.123855-51-6,tert-Butyl 4-(hydroxymethyl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.
156 6-(4-Imidazol- 1 – ylmethyl-piperidin- 1 -ylmethyl)-2-( 1 H-indazol-4- yl)-4- mophiholin-4-yl-thieno[3,2-dlpyrimidine.Via 2-chloro-6-(4-imidazol- 1 -ylmethyl-piperidin- 1 -ylmethyl)-4-morpholin-4- yl-thieno[3,2-d]pyrimidine, prepared from 4-imidazol-l-ylmethyl-piperidine.Amine preparation: To a solution of 4-hydroxymethyl-piperidine-l- carboxylic acid tert-butyl ester (250mg), in dry THF (15mL), was added carbon tetrabromide (769mg), and triphenyl phosphine (609mg). The reaction mixture was stirred at room temperature for 24 h, and then the solvents were evaporated in vacuo to give a residue which was purified by flash chromatography to give 4- bromomethyl-piperidine-1-carboxylic acid tert-butyl ester (279mg), as a colourless oil. To a solution of 4-bromomethyl-piperidine-l-carboxylic acid tert-butyl ester (240mg), in dry DMF (5.OmL), was added imidazole (129mg). The reaction mixture was heated in a sealed reaction vial at 1000C for 24 h, then cooled and the contents evaporated onto flash silica for purification. Treatment of this compound with HCl in DCM/MeOH yielded the desired amine, isolated as the hydrochloride salt. 1H NMR (400 MHz, 123855-51-6, 123855-51-6 tert-Butyl 4-(hydroxymethyl)piperidine-1-carboxylate 2764081, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; PIRAMED LIMITED; WO2006/46031; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem