Electric Literature of 118156-93-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.118156-93-7, Name is tert-Butyl 3-formylpiperidine-1-carboxylate, molecular formula is C11H19NO3. In a Article£¬once mentioned of 118156-93-7
Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors
A screening hit 1 against Trypanosoma brucei methionyl-tRNA synthetase was optimized using a structure-guided approach. The optimization led to the identification of two novel series of potent inhibitors, the cyclic linker and linear linker series. Compounds of both series were potent in a T. brucei growth inhibition assay while showing low toxicity to mammalian cells. The best compound of each series, 16 and 31, exhibited EC50s of 39 and 22 nM, respectively. Compounds 16 and 31 also exhibited promising PK properties after oral dosing in mice. Moreover, compound 31 had moderately good brain permeability, with a brain/plasma ratio of 0.27 at 60 min after IP injection. This study provides new lead compounds for arriving at new treatments of human African trypanosomiasis (HAT).
The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 118156-93-7 is helpful to your research. Electric Literature of 118156-93-7
Reference£º
Piperidine – Wikipedia,
Piperidine | C5H16609N – PubChem