With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.118133-15-6,1-(Ethoxycarbonyl)piperidine-4-carboxylic acid,as a common compound, the synthetic route is as follows.
Under anhydrous conditions, take Intermediate 14.02 (20mmol) in 25mL round bottom flask was added N,N’-carbonyldiimidazole (CDI) 4.21g (26mmol), was added freshly distilled THF 8ml, was stirred at room temperature for 4h, rotary evaporation remove THF, directly in the next reaction without purification., 118133-15-6
As the paragraph descriping shows that 118133-15-6 is playing an increasingly important role.
Reference：
Patent; Kunming Xianghao Technology Co., Ltd.; Luo Huairong; Hong Xuechuan; Zhu Xi; Zhu Jinmei; Wu Guisheng; Deng Zixin; Zhu Yingmin; Lu Yungang; Deng Ke; Qu Chunrong; (25 pag.)CN103694242; (2016); B;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem