With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1158759-03-5,tert-Butyl ((4-methylpiperidin-4-yl)methyl)carbamate,as a common compound, the synthetic route is as follows.
Step b: To a solution of 6-chloro-1-methylpyridin-2(1H)-one (55 mg, 0.383 mmol), DIPEA (200 jiL, 1.15 mmol), and tert-butyl ((4-methylpiperidin-4-yl)methyl)carbamate (96 mg, 0.42 1 mmol) in DMF (1 mL) was radiated in a microwave reactor for 2 h at 140 C. After cooling to RT, the reaction mixture was diluted with EtOAc. The organic layer was washed with sat. aq. NH4C1 (2 x) followed by brine. The organic layer was dried over Mg504, filtered, and the volatiles were removed under reduced pressure. The residue was purified by silica chromatography (0 to 100% gradient of EtOAc/heptane) to give tert-butyl ((4-methyl-i -(1- methyl-6-oxo- 1 ,6-dihydropyridin-2-yl)piperidin-4-yl)methyl)carbamate (53 mg, 0.158 mmol). ?H NMR (400 MHz, DMSO-d6) oe ppm 7.33 (dd, J=8.9, 7.4 Hz, 1 H), 6.94 (t, J=6.3 Hz, 1 H), 6.10- 6.04 (m, 1 H), 3.35 (s, 3 H), 2.95-2.85 (m, 4 H), 2.77 (s, 2 H), 1.56-1.47 (m, 2 H), 1.42-1.30 (m, ii H), 0.89 (s, 3 H). MS m/z 336.6 (M+H)
1158759-03-5, As the paragraph descriping shows that 1158759-03-5 is playing an increasingly important role.
Reference£º
Patent; NOVARTIS AG; CHEN, Zhuoliang; FORTANET, Jorge Farcia; LAMARCHE, Matthew J.; SENDZIK, Martin; TAMEZ, JR., Victoriano; YU, Bing; (237 pag.)WO2016/203405; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem