With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1075-89-4,8-Azaspiro[4.5]decane-7,9-dione,as a common compound, the synthetic route is as follows.
1075-89-4, A. Preparation of Formula (I) where m is 3, X is 3-methoxy, Y is hydrogen, R is 8-azaspiro[4.5]decan-7,9-dione and n is 2 To a solution of 0.835 g of 8-azaspiro[4.5]decan-7,9-dione in 10 ml of DMF was added 0.24 g of sodium hydride, and the mixture stirred at 80 C. for 2 hours. Then 1.0 g of (8aR,12aS,13aS)-3-methoxy-12-(3-chloropropanesulfonyl)-5,6,8a,9,10,11,12,12a,13,13a-decahydro-8H-isoquino[2,1-g][1,6]naphthyridine was added, plus a catalytic amount of sodium iodide, and the mixture stirred at 80 C. for 16 hours. After cooling, the solution was acidified with 2N hydrochloric acid and then washed with ethyl acetate, the aqueous portion basified with aqueous ammonium hydroxide and extracted further with diethylether. The solvent was then dried over sodium sulfate and evaporated under reduced pressure. The residue was flash chromatographed on silica gel, eluding with 50% ethyl acetate in hexane, to give (8aR,12aS,13aS)-3-methoxy-12-[8-(3-propyl)-8-azaspiro[4.5]decan-7,9-dione]sulfonyl-5,6,8a,9,10,11,12,12a,13,13a-decahydro-8H-isoquino[2,1-g][1,6]naphthyridine as an oil, a compound of formula (I) where n is 2.
As the paragraph descriping shows that 1075-89-4 is playing an increasingly important role.
Reference：
Patent; Syntex (U.S.A.) Inc.; US5229387; (1993); A;,
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