With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1062580-52-2,(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride,as a common compound, the synthetic route is as follows.
To the reaction flask was added 200g (3R,4R)-N-(phenylmethyl)-3-methylamino-4-methylpiperidine hydrochloride, 210g 2,4-dichloro-7H-pyrrolo[2,3-D]pyrimidine (compound II), 160g of potassium carbonate, 1000mL of water and a 500 mL of ethanol, stirring while reflux, TLC monitored the reaction. After completion of the reaction, cooled to below 30 deg. C, 2000mL of ethyl acetate was added, with stirring, suction filtered, the filter cake was washed with 200 mL of ethyl acetate, the aqueous layer was extracted with ethyl acetate 1000mL and then the combined organic phase was dried over anhydrous sodium sulfate, suction filtered, evaporated to dryness to obtain 295g crude oil, the crude was added 300mL ethyl acetate and 900mL hexane, dissolved clear, cooled to -10 deg. C overnight incubation, solid precipitation, filtration, drying, 280g white solid product compound IV.
1062580-52-2, As the paragraph descriping shows that 1062580-52-2 is playing an increasingly important role.
Reference：
Patent; Nantong Changyou Pharmaceutical Science and Technology Co., Ltd.; Li, Zebiao; Liu, Jie; Pan, Jing; Zhang, Lei; Yan, Jun; Lu, Lianling; (10 pag.)CN105732641; (2016); A;,
Piperidine – Wikipedia
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