Brief introduction of 106-52-5

106-52-5, As the paragraph descriping shows that 106-52-5 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.106-52-5,1-Methylpiperidin-4-ol,as a common compound, the synthetic route is as follows.

1-Methylpiperidin-4-ol (4 g, 34.7 mmol) was dissolved in CH2Cl2 (70 ml) at 0 C. followed by the addition of Et3N (10 ml, 69.4 mmol, 2 eq.) and methanesulfonyl chloride (2.7 ml, 34.7 mmol, 1 eq.). The mixture was stirred at RT for 3 h and quenched and extracted as in Intermediate Example 5(a). The solvent was distilled off to afford the crude product (6.7 g).

106-52-5, As the paragraph descriping shows that 106-52-5 is playing an increasingly important role.

Reference£º
Patent; Linnanen, Tero; Wohlfahrt, Gerd; Nanduri, Srinivas; Ujjinamatada, Ravi; Rajagopalan, Srinivasan; Mukherjee, Subhendu; US2015/11548; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem