Synthetic Route of 105812-81-5, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 105812-81-5, Name is (3S,4R)-4-(4-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine, SMILES is CN1C[C@@H](CO)[C@H](C2=CC=C(F)C=C2)CC1, belongs to piperidines compound. In a article, author is Yan, Li, introduce new discover of the category.
InBr3-Catalyzed Synthesis of Highly Functionalized Piperidines and Benzo[a]Pyrano[2,3-c] Phenazines
A versatile, operationally simple and highly efficient protocol for the synthesis of highly functionalized piperidines have been developed by the three-component reaction of aromatic aldehydes, aromatic amines and b-ketoesters catalyzed by InBr3 in ethanol. Also, InBr3 is demonstrated to be an efficient catalyst for synthesis of benzo[a]pyrano[2,3-c] phenazines. The significant advantages of this protocol are highlighted by excellent yields, short reaction times, avoidance of toxic solvent and broader substrate scope.
Synthetic Route of 105812-81-5, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 105812-81-5.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem