With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10338-57-5,4-(Piperidin-1-yl)benzaldehyde,as a common compound, the synthetic route is as follows.
General procedure: A mixture of the appropriate aromatic aldehydes 2b-d (12 mmol) and compound 1 (10 mmol, 2.15 g) dissolved in ethanol (50 ml) was added slowly to an aqueous solution of sodium hydroxide (12.8 mmol) in water (10 ml). The reaction mixture was stirred at 20-25 C for 4 h. The mixture was filtrated and the solid was washed with cold water. The product was crystallized from ethanol to give 3b-d., 10338-57-5
10338-57-5 4-(Piperidin-1-yl)benzaldehyde 291354, apiperidines compound, is more and more widely used in various fields.
Reference：
Article; Abdel-Wahab, Bakr F.; Abdel-Latif, Ehab; Mohamed, Hanan A.; Awad, Ghada E.A.; European Journal of Medicinal Chemistry; vol. 52; (2012); p. 263 – 268;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem