With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10338-57-5,4-(Piperidin-1-yl)benzaldehyde,as a common compound, the synthetic route is as follows.
10338-57-5, General procedure: For the reactions, 4-piperidinone or corresponding ketones (1 mmol) and 2-bromobenzaldehyde or corresponding aldehydes(2.5 mmol) were dissolved in ethanol (10 mL). The mixture wasrefluxed at 78 C and added with 0.5 mL 40% NaOH or AcOH/HCl.Reactions were monitored by TLC, when the reactions were accomplished, cooled on ice. The products could precipitate or be purified by crystallization and column chromatography using PE/EA as the eluent. Among these compounds, A4, A6, C5, D1, D2, D3 and D4 were unreported.
10338-57-5 4-(Piperidin-1-yl)benzaldehyde 291354, apiperidines compound, is more and more widely used in various fields.
Reference：
Article; Jin, Rong; Chen, Qiuxiang; Yao, Song; Bai, Encheng; Fu, Weitao; Wang, Ledan; Wang, Jiabing; Du, Xiaojing; Wei, Tao; Xu, Haineng; Jiang, Chengxi; Qiu, Peihong; Wu, Jianzhang; Li, Wulan; Liang, Guang; European Journal of Medicinal Chemistry; vol. 144; (2018); p. 218 – 228;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem