With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10338-57-5,4-(Piperidin-1-yl)benzaldehyde,as a common compound, the synthetic route is as follows.
General procedure: A mixture of 8 (1 mmol), aromatic aldehyde (1 mmol) and piperdine (2 equiv.) in isopropyl alcohol was refluxed for 4-5 h. After completion of the reaction as seen from the TLC, (eluent 7:3 /hexane:ethyl acetate) the mixture was allowed to cool to room temperature. Then the reaction mixture was poured onto ice-water and neutralized with dilute HCl. The precipitated solid was filtered, washed with water and dried under vacuum.
10338-57-5, 10338-57-5 4-(Piperidin-1-yl)benzaldehyde 291354, apiperidines compound, is more and more widely used in various fields.
Reference：
Article; Ponnuchamy, Singanan; Kanchithalaivan, Selvaraj; Ranjith Kumar, Raju; Ashraf Ali, Mohamed; Soo Choon, Tan; Bioorganic and Medicinal Chemistry Letters; vol. 24; 4; (2014); p. 1089 – 1093;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem