10315-06-7, Methyl 1-benzylpiperidine-4-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Methyl l -benzylpiperidine-4-carboxylate (.50 g, 2.1 mmol) as a solution in THF (43 mL, 0.05 M) was added to a flame dried 250 mL round bottom flask containing the Weinreb amine salt (0.26 g, 2.7 mmol, 1.25 eq) and stirred at -5C. Phenethylmagnesium chloride (8.6 mL, 8.6 mmol, 4 eq) was then added dropwise and the reaction was allowed to stir until complete consumption of starting material at -5C. After formation of the Weinreb amide the reaction was slowly warmed to room temperature and tracked by LCMS. After an additional 2 hours of stirring at room temperature the reaction was quenched with NH4C1 (20 mL) and basified with 10% NaOH. The mixture was further partitioned with EtOAc and separated. The aqueous layer was extracted with DCM (3 times). The organic layers were combined, dried over anhydrous magnesium sulfate, filtered and concentrated to afford l-(l-benzylpiperidin-4-yl)-3-phenylpropan-l-one (.630 g, 96% yield). (0633) Scaleup: Conducted as described above but scaled to 5 g of starting material. Taken on crude to hydrazine reaction.HRMS calc’d for C2iH26ON 308.20089; found [M+H] 308.20037
10315-06-7, As the paragraph descriping shows that 10315-06-7 is playing an increasingly important role.
Reference：
Patent; EMORY UNIVERSITY; COX, Bryan D.; WILSON, Lawrence J.; PROSSER, Anthony; LIOTTA, Dennis C.; SNYDER, James, P.; (98 pag.)WO2015/175855; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem