1029413-55-5, tert-Butyl 4-(4-amino-1H-pyrazol-1-yl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 2,4-dichioro-i ,3,5-triazine (0.62 g, 4.1 mmol) inN,N-dimethylformamide (DMF, 10 mE) at 0C. were added sequentially N,N-diisopropylethylamine (DIEA, 0.75 mE, 4.3 mmol) and tert-butyl 4-(4-amino-1H-pyrazol–yl)piperidine- 1 -carboxylate (Combi-l3locks, 1.0 g, 3.8 mmol). The mixture was allowed to warm to room temperature. The mixture was diluted with ethyl acetate and water. The aqueous phase basified with saturated aqueous sodium hydrogen carbonate solution and then was extracted thrice with ethyl acetate. The combined extracts were dried over anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was purified by flash chromatography (silica gel) to provide tert-butyl 4-(4-((4- chloro-i ,3,5-triazin-2-yl)amino)- 1H-pyrazol-i -yl)piperidine-i -carboxylate. ECMS-ESI (m/z): [M+H] calcd for C,5H23C1N702: 380.2. found: 379.8
1029413-55-5, As the paragraph descriping shows that 1029413-55-5 is playing an increasingly important role.
Reference£º
Patent; Gilead Sciences, Inc.; Du, Zhimin; Guerrero, Juan A.; Kaplan, Joshua A.; Knox, JR., John E.; Lo, Jennifer R.; Mitchell, Scott A.; Naduthambi, Devan; Phillips, Barton W.; Venkataramani, Chandrasekar; Wang, Peiyuan; Watkins, William J.; Zhao, Zhongdong; (593 pag.)US2016/96827; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem