1023595-19-8, 9-Boc-2,9-diazaspiro[5.5]undecane is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of (2R,6R)-4-(7-cyanopyrazolo[1,5-a]pyridin-4-yl)-6-methyl-morpholin-2- yl]methyl trifluoromethanesulfonate (compound 67c, 30 mg, 71 mumol), tert-butyl 2,9- diazaspiro[5.5]undecane-9-carboxylate (27 mg, 0.11 mmol) in ACN (4 mL) was added K2CO3 (20 mg, 0.14 mmol). After being stirred at rt for 3 hrs, the reaction mixture was diluted with ACN, and filtered through celite. The filtrate was concentrated to give a yellow solid. The solid was dissolved in DCM (2 mL), and TFA (1 mL) was added dropwise. The reaction mixture was stirred at rt for 1.5 hrs, then concentrated to give a crude product which was purified by prep- HPLC to afford Example 67 (34 mg) as a light yellow powder. MS: calc?d 427 (MH+), measured 427 (MH+).1H NMR (400 MHz, METHANOL-d4) d 8.02 (d, J = 3.5 Hz, 1H), 7.45 (d, J = 7.8 Hz, 1H), 6.56 (d, J = 7.9 Hz, 1H), 4.39 (br t, J = 9.4 Hz, 1H), 4.14 – 3.98 (m, 1H), 3.81 – 3.52 (m, 4H), 3.43 – 3.35 (m, 1H), 3.32 – 3.23 (m, 5H), 3.14 – 2.86 (m, 2H), 2.81 – 2.63 (m, 2H), 2.20 – 1.62 (m, 7H), 1.57 – 1.39 (m, 1H), 1.31 (d, J = 6.2 Hz, 3H).
1023595-19-8, As the paragraph descriping shows that 1023595-19-8 is playing an increasingly important role.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; LIU, Haixia; SHEN, Hong; ZHU, Wei; HU, Taishan; ZHANG, Zhiwei; DEY, Fabian; (91 pag.)WO2020/52738; (2020); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem