As the paragraph descriping shows that 1016258-66-4 is playing an increasingly important role.
1016258-66-4, 1-tert-Butyl 4-ethyl 4-cyanopiperidine-1,4-dicarboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
EXAMPLE 26N-((lH-Indol-2-yl)methv?-4-(aminomethv?-l-(7H-pyrrolor2.3-d1pyrimidin-4- yl)piperidine-4-carboxamide26A. 1 -(tert-Butoxycarbonyl)-4-cvanopiperidine-4-carboxylic acid; A solution of lithium hydroxide (21.25 ml, 42.50 mmol) in water was added to a stirred solution of 1-tert-butyl 4-ethyl 4-cyanopiperidine-l,4-dicarboxylate (3g, 10.63 mmol), in THF (42.5 ml) at 250C. The resulting mixture was stirred at 25 0C for 18 hours. The reaction mixture was diluted with Et2O (100 mL), and washed with water (50 mL). The aqueous layers were combined and then acidified with citric acid (IN, 50 mL). The product was extracted into DCM. The organic layer was dried over MgSO4, filtered and evaporated to afford crude product l-(tert-butoxycarbonyl)-4-cyanopiperidine-4-carboxylic acid (2.73 g, 101 %) as a yellow liquid. IH NMR (400.13 MHz, DMSO-d6) delta 1.41 (9H, s), 1.78 – 1.85 (2H, m), 2.04 (2H, d) 2.95 (2H, t), 3.96 (2H, d), 13.9 (IH, s), 1016258-66-4
As the paragraph descriping shows that 1016258-66-4 is playing an increasingly important role.
Reference£º
Patent; ASTEX THERAPEUTICS LIMITED; THE INSTITUTE OF CANCER RESEARCH:ROYAL CANCER HOSPITAL; CANCER RESEARCH TECHNOLOGY LIMITED; ASTRAZENECA AB; WO2008/75110; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem