Brief introduction of 1-Boc-Piperidine-3-acetic acid

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, Recommanded Product: 1-Boc-Piperidine-3-acetic acid, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 183483-09-2

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As part of our ongoing efforts to develop reversible inhibitors of LSD1, we identified a series of 4-(pyrrolidin-3-yl)benzonitrile derivatives that act as successful scaffold-hops of the literature inhibitor GSK-690. The most active compound, 21g, demonstrated a Kd value of 22 nM and a biochemical IC50 of 57 nM. In addition, this compound displayed improved selectivity over the hERG ion channel compared to GSK-690, and no activity against the related enzymes MAO-A and B. In human THP-1 acute myeloid leukaemia cells, 21g was found to increase the expression of the surrogate cellular biomarker CD86. This work further demonstrates the versatility of scaffold-hopping as a method to develop structurally diverse, potent inhibitors of LSD1.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H20116N – PubChem