Chemistry is an experimental science, Quality Control of: 1-(2-Chloroethyl)piperidine hydrochloride, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 2008-75-5, Name is 1-(2-Chloroethyl)piperidine hydrochloride
SAR of biphenyl carboxamide ligands of the human melanin-concentrating hormone receptor 1 (MCH R1): Discovery of antagonist SB-568849
We report here the discovery of a class of MCH R1 ligands based on a biphenyl carboxamide template. A docked-in model is presented indicating key interactions in the putative binding site of the receptor. Parallel high throughput synthetic techniques were utilised to allow rapid exploration of the structure-activity relationship around this template, leading to compound SB-568849 which possessed good receptor affinity and selectivity. This compound proved to be an antagonist with stability in vivo, an acceptable brain-blood ratio and oral bioavailability.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Quality Control of: 1-(2-Chloroethyl)piperidine hydrochloride, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 2008-75-5, in my other articles.
Reference£º
Piperidine – Wikipedia,
Piperidine | C5H10951N – PubChem