On June 30, 2016, Bradner, James; Buckley, Dennis; Winter, Georg published a patent.Application of 1216805-11-6 The title of the patent was Methods to induce targeted protein degradation through bifunctional molecules. And the patent contained the following:
The present application provides bifunctional compounds which act as protein degradation inducing moieties. The present application also relates to methods for the targeted degradation of endogenous proteins through the use of the bifunctional compounds that link a cereblon-binding moiety to a ligand that is capable of binding to the targeted protein which can be utilized in the treatment of proliferative disorders. The present application also provides methods for making compounds of the application and intermediates thereof. The experimental process involved the reaction of 2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindoline-5-carboxylic acid(cas: 1216805-11-6).Application of 1216805-11-6
The Article related to targeted protein degradation bifunctional mol preparation, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application of 1216805-11-6
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem