《Discovery of AZD3514, a small-molecule androgen receptor downregulator for treatment of advanced prostate cancer》 was written by Bradbury, Robert H.; Acton, David G.; Broadbent, Nicola L.; Brooks, A. Nigel; Carr, Gregory R.; Hatter, Glenn; Hayter, Barry R.; Hill, Kathryn J.; Howe, Nicholas J.; Jones, Rhys D. O.; Jude, David; Lamont, Scott G.; Loddick, Sarah A.; McFarland, Heather L.; Parveen, Zaieda; Rabow, Alfred A.; Sharma-Singh, Gorkhn; Stratton, Natalie C.; Thomason, Andrew G.; Trueman, Dawn; Walker, Graeme E.; Wells, Stuart L.; Wilson, Joanne; Wood, J. Matthew. Synthetic Route of C10H14N2O And the article was included in Bioorganic & Medicinal Chemistry Letters on April 1 ,2013. The article conveys some information:
Removal of the basic piperazine nitrogen atom, introduction of a solubilising end group and partial reduction of the triazolopyridazine moiety in the previously-described lead androgen receptor downregulator 6-[4-(4-cyanobenzyl)piperazin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine (1) addressed hERG and phys. property issues, and led to clin. candidate 6-(4-{4-[2-(4-acetylpiperazin-1-yl)ethoxy]phenyl}piperidin-1-yl)-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazine (12), designated AZD3514, that is being evaluated in a Phase I clin. trial in patients with castrate-resistant prostate cancer. In the experimental materials used by the author, we found 4-(Pyridin-3-yl)piperidin-4-ol(cas: 50461-59-1Synthetic Route of C10H14N2O)
4-(Pyridin-3-yl)piperidin-4-ol(cas: 50461-59-1) belongs to piperidines. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions. Synthetic Route of C10H14N2O
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem