Synthesis and NK1/NK2 binding activities of a series of diacyl-substituted 2-arylpiperazines was written by Blythin, David J.;Chen, Xiao;Piwinski, John J.;Shih, Neng-Yang;Shue, Ho-Jane;Anthes, John C.;McPhail, Andrew T.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2002.Application In Synthesis of tert-Butyl 4-aminopiperazine-1-carboxylate This article mentions the following:
The synthesis and binding affinity for hNK1 and hNK2 receptors of a series of diacyl substituted 2-aryl piperazines are described. SAR evaluation led to one racemic derivative as an apparent dual inhibitor. Chiral chromatog. separation of racemic derivative led to the observation that NK1 activity was shown by one enantiomer and NK2 activity was shown by the other enantiomer. X-ray crystallog. anal. of the crystalline di-BOC derivative of the NK2 active piperazine showed that the 2R configuration was associated with NK2 activity. Further derivatization indicated that dual NK1/NK2 activity could be built into the 2R series. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-aminopiperazine-1-carboxylate (cas: 118753-66-5Application In Synthesis of tert-Butyl 4-aminopiperazine-1-carboxylate).
tert-Butyl 4-aminopiperazine-1-carboxylate (cas: 118753-66-5) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Application In Synthesis of tert-Butyl 4-aminopiperazine-1-carboxylate
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem