Blizzard, Timothy A.; Chen, Helen; Kim, Seongkon; Wu, Jane; Bodner, Rena; Gude, Candido; Imbriglio, Jason; Young, Katherine; Park, Young-Whan; Ogawa, Aimie; Raghoobar, Susan; Hairston, Nichelle; Painter, Ronald E.; Wisniewski, Doug; Scapin, Giovanna; Fitzgerald, Paula; Sharma, Nandini; Lu, Jun; Ha, Sookhee; Hermes, Jeff; Hammond, Milton L. published an article on February 1 ,2014. The article was titled 《Discovery of MK-7655, a β-lactamase inhibitor for combination with Primaxin》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.Recommanded Product: 1-Cbz-4-Methylaminopieridine The information in the text is summarized as follows:
β-Lactamase inhibitors with a bicyclic urea core and a variety of heterocyclic side chains were prepared and evaluated as potential partners for combination with imipenem to overcome class A and C β-lactamase mediated antibiotic resistance. The piperidine analog 3 (MK-7655) inhibited both class A and C β-lactamases in vitro. It effectively restored imipenem’s activity against imipenem-resistant Pseudomonas and Klebsiella strains at clin. achievable concentrations A combination of MK-7655 and Primaxin is currently in phase II clin. trials for the treatment of Gram-neg. bacterial infections. In the experiment, the researchers used many compounds, for example, 1-Cbz-4-Methylaminopieridine(cas: 405057-75-2Recommanded Product: 1-Cbz-4-Methylaminopieridine)
1-Cbz-4-Methylaminopieridine(cas: 405057-75-2) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Recommanded Product: 1-Cbz-4-Methylaminopieridine
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem