On June 25, 2020, Blanc, Jean-Baptiste; Cheng, Zhanling; Han, Xingchun; Khan, Nawaz; Kramer, Christian; Kuehne, Holger; Lerner, Christian; Nettekoven, Matthias; Pflieger, Philippe; Puellmann, Bernd; Schmitt, Sebastien; Stoll, Theodor; Wang, Jianhua; Wang, Yongguang; Yang, Song published a patent.Recommanded Product: tert-Butyl 3-(piperidin-4-yl)azetidine-1-carboxylate The title of the patent was Novel imidazopyrazine derivatives as antibacterials and their preparation. And the patent contained the following:
The invention provides imidazopyrazine derivatives having formula I, and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and related diseases. Compounds of formula I wherein R1 is (un)substituted C1-6 alkyl; R11 is H, halo and C1-6 alkyl; R1R11 can be taken together to form β-, γ-, δ- and ε-lactam; R2 is H, C1-6 alkyl, C1-6 haloalkyl, C1-6 cyanoalkyl, etc.; R3 is H, halo, C1-6 alkyl, NO2, CN, etc.; R4 and R10 are independently H, halo and (un)substituted C1-6 alkyl; R5, R6, R7, R8 and R9 are independently H, halo, amino, C1-6 alkoxycarbonyl-C1-6 alkoxy, etc.; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by amidation of 4-amino-2-methylbenzoic acid with dimethylamine hydrochloride; the resulting 4-amino-N,N,2-trimethylbenzamide underwent arylation with 8-chloro-3-(2,3-difluoro-4-methoxyphenyl)imidazo[1,2-a]pyrazine to give compound II. The invention compounds were evaluated for their antibacterial activity. From the assay, it was determined that compound II exhibited IC90 value of 0.12μM. The experimental process involved the reaction of tert-Butyl 3-(piperidin-4-yl)azetidine-1-carboxylate(cas: 1251006-64-0).Recommanded Product: tert-Butyl 3-(piperidin-4-yl)azetidine-1-carboxylate
The Article related to imidazopyrazine antibacterial, Heterocyclic Compounds (More Than One Hetero Atom): Other 6-Membered Rings, Two Hetero Atoms and other aspects.Recommanded Product: tert-Butyl 3-(piperidin-4-yl)azetidine-1-carboxylate
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem