Product Details of 59234-40-1On September 30, 1982 ,《The effects of cyclic dicarboxylic acids on spontaneous and amino acid-evoked activity of rat cortical neurons》 was published in British Journal of Pharmacology. The article was written by Birley, S.; Collins, J. F.; Perkins, M. N.; Stone, T. W.. The article contains the following contents:
At relatively low ejecting currents (10-25 nA), cis-2,3-piperidinedicarboxylic acid (I) [46026-75-9] had no effect on spontaneous firing in neurons of rat cerebral cortex, but selectively antagonized the excitation evoked by N-methyl-D-aspartate (II) without affecting responses to quisqualate or kainate. At higher ejecting currents (60-100 nA), responses to all 3 agonists were reduced. Other cis-piperidinedicarboxylic acids and piperazine-2,3-dicarboxylic acid [84619-47-6] had only weak and variable effects on cell firing and responses to II, quisqualate, kainate, glutamate, and aspartate. Excitation was produced by 2,3-pyridinedicarboxylic acid (quinolinic acid) [89-00-9] in all cortical neurons tested. Thus, quinolinic acid may be of physiol. interest as a potential endogenous excitant in the nervous system and I and its N-Me derivative may be of use in studies of receptor pharmacol. and the identification of synaptic transmitters. In the experiment, the researchers used many compounds, for example, Cis-piperidine-2,6-dicarboxylic acid(cas: 59234-40-1Product Details of 59234-40-1)
Cis-piperidine-2,6-dicarboxylic acid(cas: 59234-40-1) is a member of piperidine. Piperidine-containing compounds are also frequently employed in synthesis as ligands or auxiliaries. Accordingly, many efforts have been devoted to the development of novel methods for the synthesis of these compounds over the years.Product Details of 59234-40-1
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem