Soluble epoxide hydrolase pharmacological inhibition ameliorates experimental acute pancreatitis in mice was written by Bettaieb, Ahmed;Chahed, Samah;Bachaalany, Santana;Griffey, Stephen;Hammock, Bruce D.;Haj, Fawaz G.. And the article was included in Molecular Pharmacology in 2015.Name: 1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea The following contents are mentioned in the article:
Acute pancreatitis (AP) is an inflammatory disease, and is one of the most common gastrointestinal disorders worldwide. Soluble epoxide hydrolase (sEH; encoded by Ephx2) deficiency and pharmacol. inhibition have beneficial effects in inflammatory diseases. Ephx2 whole-body deficiency mitigates exptl. AP in mice, but the suitability of sEH pharmacol. inhibition for treating AP remains to be determined We investigated the effects of sEH pharmacol. inhibition on caerulein- and arginine-induced AP using the selective sEH inhibitor 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU), which was administered before and after induction of pancreatitis. Serum amylase and lipase levels were lower in TPPU-treated mice compared with controls. In addition, circulating levels and pancreatic mRNA of the inflammatory cytokines tumor necrosis factor-伪, interleukin Il-1尾, and Il-6 were reduced in TPPU-treated mice. Moreover, sEH pharmacol. inhibition before and after induction of pancreatitis was associated with decreased caerulein- and arginine-induced nuclear factor-魏B inflammatory response, endoplasmic reticulum stress, and cell death. sEH pharmacol. inhibition before and after induction of pancreatitis mitigated caerulein- and arginine-induced AP. This work suggests that sEH pharmacol. inhibition may be of therapeutic value in acute pancreatitis. This study involved multiple reactions and reactants, such as 1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea (cas: 1222780-33-7Name: 1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea).
1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea (cas: 1222780-33-7) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Name: 1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem