Interactions between N-methyl-D-aspartate receptor antagonists and the discriminative stimulus effects of morphine in rats was written by Bespalov, Anton Y.;Beardsley, Patrick M.;Balster, Robert L.. And the article was included in Pharmacology, Biochemistry and Behavior in 1998.Recommanded Product: 119431-25-3 This article mentions the following:
N-methyl-D-aspartate (NMDA) receptor antagonists alter some pharmacol. and behavioral effects of acute and chronic opioid administration. The interactions of NMDA antagonists with the discriminative stimulus properties of morphine were studied in adult male Long-Evans rats. The rats were trained to discriminate 3.2 mg/kg of s.c. morphine from water under a 2-lever fixed-ratio 10 schedule of food reinforcement. During test sessions, i.p. injections of the non-competitive NMDA receptor antagonist dizocilpine (0.03-0.2 mg/kg), the competitive antagonists NPC-17742 (1-16 mg/kg) and SDZ 220-581 (0.1-3 mg/kg), the polyamine site antagonist eliprodil (3-17.3 mg/kg), the glycine site partial agonist (+)-HA-966 (3-56 mg/kg), and the nonselective glutamate antagonist kynurenic acid (30-150 mg/kg) were coadministered with s.c. morphine (1-3.2 mg/kg; interaction tests) or water (generalization tests). In the generalization tests, none of the compounds completely substituted for morphine. Concurrent administration of morphine and NMDA antagonists did not greatly alter the discriminative stimulus properties of morphine. Various doses of NPC-17742, SDZ 220-581, or (+)-HA-966 somewhat increased the levels of morphine-appropriate lever selection, whereas some attenuation of morphine lever selection was obtained when morphine was coadministered with eliprodil. Thus, NMDA antagonists have minimal interactions with the discriminative stimulus effects of morphine. In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol (cas: 119431-25-3Recommanded Product: 119431-25-3).
1-(4-Chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol (cas: 119431-25-3) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N鈥揌 bond in an axial position, and the other in an equatorial position.Recommanded Product: 119431-25-3
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem