Discovery of SARxxxx92, a pan-PIM kinase inhibitor, efficacious in a KG1 tumor model was written by Barberis, Claude;Erdman, Paul;Czekaj, Mark;Fire, Luke;Pribish, James;Tserlin, Elina;Maniar, Sachin;Batchelor, Joseph D.;Liu, Jinyu;Patel, Vinod F.;Hebert, Andrew;Levit, Mikhail;Wang, Anlai;Sun, Frank;Huang, Shih-Min A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020.Product Details of 882033-93-4 The following contents are mentioned in the article:
N-substituted azaindoles were discovered as potent pan-PIM inhibitors. Lead optimization, guided by structure and focused on physico-chem. properties allowed us to solve inherent hERG and permeability liabilities, and provided compound I, which subsequently impacted KG-1 tumor growth in a mouse model. This study involved multiple reactions and reactants, such as (3S,4R)-rel-tert-Butyl 3-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate (cas: 882033-93-4Product Details of 882033-93-4).
(3S,4R)-rel-tert-Butyl 3-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate (cas: 882033-93-4) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Product Details of 882033-93-4
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem