Design and synthesis of N’-phenylacylhydrazide safety-catch resin and its application in synthesis of p-nitroaniline chromogenic peptide substrates was written by Bai, Guo-liang;Yang, Xiao-xiao;Lin, Hao;Yang, Li-quan;Wang, De-xin. And the article was included in Huaxue Shiji in 2012.Category: piperidines The following contents are mentioned in the article:
N’-Phenylacylhydrazide safety-catch resin was synthesized by derivatizing com. available MBHA resin with N’-Boc-4-hydrazinobenzoic acid. N’-Protection form of 4-hydrazinobenzoic acid and initial amino functional resin type have been investigated to achieve higher derivation yield. Five serine protease peptidyl-pNA chromogenic substrates were synthesized with the safety-catch resin by Boc/Fmoc hybridized protocol with high yields and purity. Intermediates and product were characterized by HRMS and NMR. This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5Category: piperidines).
(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Category: piperidines
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem