Design and synthesis of N’-phenylacylhydrazide safety-catch resin and its application in synthesis of p-nitroaniline chromogenic peptide substrates was written by Bai, Guo-liang;Yang, Xiao-xiao;Lin, Hao;Yang, Li-quan;Wang, De-xin. And the article was included in Huaxue Shiji in 2012.Recommanded Product: (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid The following contents are mentioned in the article:
N’-Phenylacylhydrazide safety-catch resin was synthesized by derivatizing com. available MBHA resin with N’-Boc-4-hydrazinobenzoic acid. N’-Protection form of 4-hydrazinobenzoic acid and initial amino functional resin type have been investigated to achieve higher derivation yield. Five serine protease peptidyl-pNA chromogenic substrates were synthesized with the safety-catch resin by Boc/Fmoc hybridized protocol with high yields and purity. Intermediates and product were characterized by HRMS and NMR. This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5Recommanded Product: (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid).
(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Recommanded Product: (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem