Chemistry is an experimental science, Safety of (R)-1-Boc-3-(Aminomethyl)piperidine, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 140645-23-4, Name is (R)-1-Boc-3-(Aminomethyl)piperidine
Binding interaction of human serum albumin (HSA) with allura red AC, a food colourant, was investigated at the molecular level through fluorescence, ultraviolet-visible, circular dichroism (CD) and Raman spectroscopies, as well as protein-ligand docking studies to better understand the chemical absorption, distribution and transportation of colourants. Results show that allura red AC has the ability to quench the intrinsic fluorescence of HSA through static quenching. The negative values of the thermodynamic parameters DeltaG, DeltaH, and DeltaS indicated that hydrogen bond and van der Waals forces are dominant in the binding between the food colourant and HSA. The CD and Raman spectra showed that the binding of allura red AC to HSA induces the rearrangement of the carbonyl hydrogen-bonding network of polypeptides, which changes the HSA secondary structure. This colourant is bound to HSA in site I, and the binding mode was further analysed with the use of the CDOCKER algorithm in Discovery Studio.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Safety of (R)-1-Boc-3-(Aminomethyl)piperidine, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 140645-23-4, in my other articles.
Reference：
Piperidine – Wikipedia,
Piperidine | C5H16692N – PubChem