Synthetic Route of 19916-73-5, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 19916-73-5, Name is 6-(Benzyloxy)-7H-purin-2-amine, SMILES is C3=NC1=C(C(=NC(=N1)N)OCC2=CC=CC=C2)[NH]3, belongs to piperidines compound. In a article, author is Li, Huang-Yi, introduce new discover of the category.
Synthesis of (3S,4S,5S)-trihydroxylpiperidine derivatives as enzyme stabilizers to improve therapeutic enzyme activity in Fabry patient cell lines
A series of 3S,4S,5S-trihydroxylated piperidines bearing structural diversity at C-2 or C-6 positions has been synthesized and tested to determine their ability to stabilize the activity of recombinant human alpha-Galactosidase A (rh-alpha-Gal A). Hit molecules were identified by rapid inhibitory activity screening, and then further investigated for their ability to protect this enzyme from thermo-induced denaturation and enhance its activity in Fabry patient cell lines. Our study resulted in the identification of a new class of small molecules as enzyme stabilizers for the potential treatment of Fabry disease. Of these, stabilizer 21 was the most effective, showing a 12-fold increase in rh-alpha-Gal A activity in Fabry disease cell lines. (C) 2017 Elsevier Masson SAS. All rights reserved.
Synthetic Route of 19916-73-5, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 19916-73-5 is helpful to your research.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem